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MolES Seminar: Dr. Brent Nannenga (Arizona State University)
MolES Seminar: Dr. Brent Nannenga (Arizona State University)
WhenTuesday, Apr 23, 2019, 1 – 2 p.m.
Campus locationMolecular Engineering (MOL)
Campus roomNanoES 181
Event typesLectures/Seminars
Event sponsorsMolecular Engineering and Sciences

Molecular Engineering and Sciences Seminar Series
High-resolution structure determination by microcrystal electron diffraction
Abstract: A common barrier to high-resolution structure determination is the growth of large well-ordered crystals. Electron diffraction is capable of producing high-quality diffraction data from crystals that are orders of magnitude smaller than those needed for conventional X-ray crystallographic experiments, and 3D electron diffraction methods have recently begun to yield high-resolution structures from extremely small microcrystals. In this presentation, the cryo-electron microscopy technique of microcrystal electron diffraction, or MicroED, will be described in detail along with representative structures determined by the method. Additionally, current work in our lab, which is focused on improving MicroED methodology and extending this technique to new samples will be presented.

Bio: Brent Nannenga is currently an Assistant Professor of Chemical Engineering in the School for Engineering Matter, Transport and Energy at Arizona State University and a member of The Biodesign Institute’s Center for Applied Structural Discovery. He received his Ph.D. in Chemical Engineering from the University of Washington in 2011 under the supervision of François Baneyx. Following his graduate studies, he conducted postdoctoral research at Janelia Research Campus (Howard Hughes Medical Institute) in the lab of Tamir Gonen, where he focused on the development and application of cryo-electron microscopy (cryo-EM), specifically the development of microcrystal electron diffraction (MicroED). Since joining Arizona State University in 2015, his research has focused on developing and using methods for high-resolution structure determination, and employing structural insights gained from these methods in order to engineer biomolecules and materials with novel and unique properties. His work has been recognized by awards including an Air Force Office of Scientific Research (AFOSR) Young Investigator Award, and a Fulton Outstanding Assistant Professor Award. His work is supported by the AFOSR and the National Institutes of Health.

This weekly seminar brings together students, faculty and invited guests from various disciplines across campus to explore current trends in molecular engineering and nanotechnology. It is a forum for active interdisciplinary discussions. These talks are open to the public and attract a diverse audience of students and faculty.…
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