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MolES Seminar: Dr. Brad Pentulute (MIT)
MolES Seminar: Dr. Brad Pentulute (MIT)
WhenTuesday, Feb 26, 2019, 1 – 2 p.m.
Campus locationMolecular Engineering (MOL)
Campus roomNanoES 181
Event typesLectures/Seminars
Event sponsorsMolecular Engineering and Sciences

Molecular Engineering and Sciences Seminar Series
Cysteine arylation to engineer, deliver, and discover proteins

Here we report a robust bioconjugation method using cysteine arylation. This chemistry enables site-specific conjugation at cysteine residues within peptides, proteins, and antibodies. Our two developed approaches use either perfluoroaryl-cysteine SNAr chemistry or organometallic palladium reagents. This work lead to the discovery of a self-labeling four-residue sequence that enables regioselective conjugation at only one cysteine residue within an intact antibody containing natural amino acids. Recently, we discovered a new approach for the native conjugation of complex natural products such as vancomycin onto peptides and proteins without the introduction of linkers or chemical handles.

This weekly seminar brings together students, faculty and invited guests from various disciplines across campus to explore current trends in molecular engineering and nanotechnology. It is a forum for active interdisciplinary discussions. These talks are open to the public and attract a diverse audience of students and faculty.
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