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MolES/Nano Seminar: K. Dane Wittrup, Massachusetts Institute of Technology - Chemical Engineering & Biological Engineering
WhenTuesday, Mar. 11, 2014, 2:30 – 3:30 p.m.
Description

Speaker's Website
Host: Assoc. Prof. Wendy Thomas, Dept. Bioengineering

Multitasking Anti-cancer Biotherapeutics

Combining multiple binding domains into single macromolecular assemblies enables novel approaches to cancer therapeutic development.  Examples of such multispecific strategies will be presented, including:  pretargeted radioimmunotherapy;  triepitopic receptor clustering and downregulation;  and targeted endosomal potentiation for macromolecular payload release.  The primary synthetic approach is to use combinatorial libraries of protein displayed on the surface of yeast cells, and to select the desired binding properties by directed evolution.  A common analytical thread throughout this work is to formulate simple, reductionist kinetic schema for these complex systems that help to elucidate key parameters and rate processes.

Campus locationJohnson Hall (JHN)
Campus room175
Event typesLectures/Seminars
Event sponsorsThe weekly seminar series organized by Molecular Engineering and Sciences Institute provides a forum for bringing national and international leaders in nanoscale science and technology to campus, and for graduate students enrolled in our Dual Ph.D. program in Nanotechnology to present their research. The campus and public are welcome to attend.
Linkdepts.washington.edu…
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