Targeting kynurenine metabolism in aging and age-associated disease

George Sutphin, PhD

Assistant Professor

Molecular & Cellular Biology

BIO5 Institute

University of Arizona

Why Attend this Seminar? 

Tryptophan is an essential amino acid that our cells use to build proteins and produce neurotransmitters and other bioactive metabolites. The majority of ingested tryptophan is metabolized through the kynurenine pathway. This seminar will discuss recent evidence that inhibiting enzymes or supplementing metabolites in the kynurenine pathway can extend healthy lifespan and improve age-associated pathology in both the roundworm Caenorhabditis elegans and mice. We will focus specifically on the benefits of the kynurenine metabolite 3-hydroxyanthranilic acid for extending healthy lifespan and promoting pathogen resistance during aging.

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Sign-in is required for students registered in PATH 520. All other attendees are encouraged to track attendance and complete an evaluation of the presentation.