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Thesis Defense -Characterizing Aztreonam Resistance in Pseudomonas aeruginosa through Artificial Selection and Whole Genome Sequencing by Kathryn McLean
WhenFriday, May 19, 2017, 1 – 3 p.m.
Campus locationUW Medical Center
Campus roomRR110
Event typesAcademics
Description

Aztreonam is a relatively new antibiotic which is being increasingly used to treat cystic fibrosis patients with Pseudomonas aeruginosa airway infections. As for all antimicrobial agents, bacteria can evolve resistance and decrease the effectiveness of the drug; however, the mechanisms and consequences of aztreonam resistance are incompletely understood. Using experimental evolution, we have cataloged spontaneous mutations conferring aztreonam resistance and have explored their effects on bacterial fitness, the potential for cross resistance, and virulence within a host.

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